Early exposure to BPA ( Bisphenol A ), an additive commonly found in plastic water bottles and soup can liners, causes an increased cancer risk in an animal model of human prostate cancer.
The increased risk can be traced to prostate stem and progenitor cells which become sensitized to estrogen early in development through exposure to BPA, which mimics estrogen in the body.
Environmental exposure to compounds like BPA that mimic hormones has become common.
Prostate stem cells, which are very long-lived, pass on the increased estrogen sensitivity to the prostate tissues they produce throughout life. Because prostate cancer is fueled in part by naturally rising estrogen levels in aging men, the prostate tissue's increased sensitivity to estrogen makes the development of cancer much more likely.
Studies of expectant mothers in the United States showed that more than 95% of them had BPA in their urine, which means they recently ingested these compounds.
Previous studies by Gail Prins and colleagues using rats showed that exposure to elevated estrogen or BPA during embryonic development increased the rate of prostate cancer later in life. To determine if there was a link in humans, Prins developed a new animal model using human prostate stem cells implanted into mouse hosts.
Prins, a researcher from University of Illinois at Chicago, took human prostate stem cells from deceased young adult male organ donors and implanted the cells into mice, where they formed human prostate tissue. To mimic exposure to BPA during early prostate development, Prins fed the mice BPA for the first two weeks after the transplant, at doses in line with those seen in pregnant American women. The tissue was then allowed to mature for a month into a human prostate-like tissue.
Next, Prins exposed the mice to elevated estrogen levels for two to four months, to mimic the normal rise in estrogen seen in aging men. Signs of cancer developed in the human prostate tissue in a third of the mice fed BPA, as compared to only 12% in mice that had not been fed BPA. If the stem cells were exposed to BPA before implantation and again during development, 45% showed signs of cancer.
Researchers believe that BPA reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility for diseases including cancer. ( Xagena )
Source: University of Illinois at Chicago, 2013